Studies on pathogenic mechanisms of prion diseases and evaluation of prion strains properties [Elektronische Ressource] / from Mohamed Karmi Hussein Mahmoud

Institute of Animal Pathology Faculty of Veterinary Medicine Ludwig Maximilians University Munich Chair: Prof. Dr. Walter Hermanns Doctoral Studies Performed in the Institute of Neuropathology and Prion Research Faculty of Medicine Ludwig Maximilians University Munich Under Supervision of Prof. Dr. Hans Kretzschmar Studies on Pathogenic Mechanisms of Prion Diseases and Evaluation of Prion Strains Properties A Thesis Submitted for the Doctor Degree in Veterinary Medicine Faculty of Veterinary Medicine Ludwig Maximilians University Munich From Mohamed Karmi Hussein Mahmoud Aswan-Egypt Munich 2009 Gedruckt mit Genemigung der Tierärztlichen Fakultät Der Ludwig Maximilians University Munich Dekan: Universität-Professor Dr. J. Braun Referent: Universität-Professor Dr. W. Hermanns Koreferent: Universität-Professor Dr. W. Klee Tag der Promotion: 6.Februar 2009 2 This work is dedicated to my parents, my wife and my son Abd El-Rahman 3Table of Contents Page 1. Introduction……………………………………………………………….13 1.1. The Prion…………………………………………………………………………….13 1.2. The Prion Diseases and Neurodegeneration……………………………………15 1.3.