Structure elucidation and total synthesis of complex polyketides and development of direct methods for the synthesis of chiral amines [Elektronische Ressource] / vorgelegt von Dirk Menche

Structure Elucidation and Total Synthesis of Complex Polyketides and Development of Direct Methods for the Synthesis of Chiral Amines HABILITATIONSCHRIFT Der Naturwissenschaftlichen Fakultät vorgelegt von Dr. Dirk Menche Hannover, März 2007 All results discussed within this report have been part of publications or are prepared for [52,55,57,88,94,98,103,109,110,123,128,137,139,146]publication. TABLE OF CONTENTS GENERAL SECTION..............................................................................1 1 Introduction............................................................................................................... 1 2 Structural Elucidation and Total Synthesis of the Archazolids............................ 6 2.1 Introduction.. 6 2.2 Isolation and Structural Elucidation............................................................................ 7 2.2.1 Stereochemical Determination of Archazolid A and B............................................... 7 2.2.2 Archazolid-7-O-β-D-glucopyranoside from the Myxobacterium Cystobacter violaceus: Isolation, Structural Elucidation and Solution Conformation.................. 13 2.2.3 Archazolid D: The First Hydroxylated Archazolid................................................... 20 2.3 Total Synthesis of Archazolid A............................................................................... 23 2.