Structure determination and biochemical characterization of the protein ubiquitin ligases SCF_1hnF_1hnb_1hnw_1hn7 and APC [Elektronische Ressource] / by Stephanie Schumann

Structure Determination and Biochemical Characterization of Fbw7the Protein Ubiquitin Ligases SCF and APC Dissertation In fulfillment of the requirements for the degree of doctor rerum naturalium (Dr. rer. nat.) submitted to the Faculty of Mathematics and Natural Sciences, Martin-Luther-University Halle-Wittenberg, Germany by Stephanie Schumann date of birth, 13.04.1977 in Wippra, Germany Reviewing Professors 1. Prof. Dr. Milton T. Stubbs 2. Prof. Dr. Nikola P. Pavletich 3. Prof. Dr. Stefan Jentsch Halle (Saale), 4. October 2007 urn:nbn:de:gbv:3-000012609[http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000012609] I dedicate this work to my parents, Rosemarie and Gerd Oehlmann Parts of this work are in preparation for publication. Oehlmann, S., Hao, B., Sowa, M., Harper, W.J., and Pavletich, N.P.. Structure of a Fbw7-Skp1-CyclinE Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases. Mol. Cell, submitted for publication. Index Index I Acknowledgements VI Declartion VI List of Abbrevations VIII List of Figures IX List of Tables XI 1. Introduction 1 1.1 Eukaryotic cell cycle control and cancer 1 1.