Structure and function of RNA polymerase I subunits [Elektronische Ressource] / Sebastian R. Geiger

Dissertation zur Erlangung des Doktorgrades der Fakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität München Structure and function of RNA polymerase I subunits Sebastian R. Geiger aus München 2010 Erklärung Diese Dissertation wurde im Sinne von §13 Abs. 3 der Promotionsordnung vom 29. Januar 1998 von Herrn Prof. Dr. Patrick Cramer betreut. Ehrenwörtliche Versicherung Diese Dissertation wurde selbständig und ohne unerlaubte Hilfe erarbeitet. München, am __. Juni 2010 _____________________ Sebastian Geiger Dissertation eingereicht am 11. Juni 2010 1. Gutachter: Prof. Dr. Patrick Cramer 2. Gutachter: Prof. Dr. Dietmar Martin Mündliche Prüfung am 16. Juli 2010 2 Acknowledgements Acknowledgements First of all, I would like to thank Professor Doctor Patrick Cramer for the opportunity to perform this fascinating research in his group and within the rich scientific environment of the Gene Center. Moreover I thank Patrick for his constant and strong support and his respectful and friendly attitude. His high motivation and never-ending passion for science inspired me throughout my thesis. I would like to thank all present and former members of the Cramer laboratory for their help, all the stimulating discussions and the enjoyable atmosphere in the lab. Thanks to Claus for his pioneering work in the RNA Polymerase I field, which paved the way for the projects of this thesis.