Structure and exchange dynamics of the apical domains of the thermosome and human saposins by NMR spectroscopy [Elektronische Ressource] / Michael John

Department Chemie der Technischen Universitt Mnchen Structure and Exchange Dynamics of the Apical Domains of the Thermosome and Human Saposins by NMR Spectroscopy Michael John Vollstndiger Abdruck der von der Fakult t Chemie der Technischen Universitt Mnchen zur Erlangung des akademischen Grades eines Doktors der Naturwissenschaften genehmigten Dissertation. Vorsitzender: Univ.-Prof. Dr. J. Buchner Prüfer der Dissertation: Univ.-Prof. Dr. H. Kessler Univ.-Prof. Dr. W. Domcke Priv.-Doz. Dr. G. Gemmecker Die Dissertation wurde am 30.06.2004 bei der Technischen Universitt Mnchen eingereicht und durch die Fakult t fr Chemie am 27.07.2004 angenommen.üü äü ä äü ä dedicated to my parents In theory, there is no difference between theory and practice. In practice, however, there is. - Unknown Abstract NMR spectroscopy provides a versatile and indispensable methodology for the characterisation of molecular structure and dynamics in modern biochemical research. A part of the present work focuses on fast structural predictions, derived from major NMR parameters and from their similarity between sequence-related proteins.