Structural and biophysical studies of adhesive binding by classical cadherins [Elektronische Ressource] / Julia Brasch

Structural and Biophysical Studies of Adhesive Binding by Classical Cadherins Von der Naturwissenschaftlichen Fakultät der Gottfried Wilhelm Leibniz Universität Hannover zur Erlangung des Grades Doktorin der Naturwissenschaften Dr. rer. nat. genehmigte Dissertation von Dipl.-Biochem. Julia Brasch geboren am 16. Januar 1982 in Braunschweig 2011 Referent: Prof. Dr. rer. nat. Bernd Otto Korreferent: Prof. Dr. rer. nat. Walter Müller Drittprüfer: Prof. Dr. Lawrence S. Shapiro Weitere Prüfer: Prof. Dr. rer. nat. Hans-Jörg Jacobsen Tag der Promotion: 21. April 2011 The present study was carried out at the Institute of Molecular Biophysics and Biochemistry, Columbia University in the City of New York, in the Laboratory of Prof. Dr. Lawrence Shapiro in collaboration with Prof. Dr. Bernd Otto, at the Institute of Biochemistry, Tiermedizinische Hochschule Hannover. Parts of this thesis have been published in: Brasch J, Harrison OJ, Ahlsen G, Carnally SM, Henderson RM, Honig B, Shapiro L. (2010) Structure and binding mechanism of vascular endothelial cadherin, a divergent classical cadherin. Journal of Molecular Biology, 408 (1): 57-73. Harrison OJ, Jin, X, Hong S, Bahna F, Ahlsen G, Brasch J, Wu Y, Vendome J, Felsovalyi K, Hampton CM, Troyanovsky RB, Ben-Shaul A, Frank J, Trojanovksy SM, Shapiro L, Honig B.