Streptamer technology allows to isolate leukemia antigen-specific CD8_1hn+ T cells [Elektronische Ressource] / presented by Xinchao Wang

UniversitätRostockZentrum fϋr Innere MedizinMedizinische KlinikGeschäftsfϋhrender Direktor: Prof. Dr. med. Mathias FreundStreptamer technology allows to isolate+leukemia antigen-specific CD8 T cellsDissertationApplying for the Doctoral Degree of Medicine (Dr. med.)Faculty of Medicine, University of RostockPresented byXinchao Wangthborn July 4 1969 in Henan, P.R.ChinaRostock, November 10, 2009urn:nbn:de:gbv:28-diss2009-0196-0+Xinchao WANG Streptamer isolated WT1-specific CD8 Tcels II1. Gutachter: Prof. Dr. med. Michael Schmitt, Medizinische Klinik III,Universitaetsklinikum Rostock2. Gutachter: Prof. Dr. med. Jochen Greiner, Klinik fuer Innere MedizinIII, Universitaetsklinikum Ulm3. Gutachter: Prof. Dr. med. Ernst Klar, Chirurgische Klinik undPoliklinik, Universitaetsklinikum Rostock+Xinchao WANG Streptamer isolated WT1-specific CD8 Tcels IIITo my family+Xinchao WANG Streptamer isolated WT1-specific CD8 Tcels IVContentsList of Abbreviations…………………………………………………………………1. Introduction ………………………………………………………………………… 11.1 Donor lymphocyte infusion (DLI)……………………………………………………11.2 Graft-versus-host disease (GVHD)…………11.3 Wilms’ tumor gene 1 (WT1)…………………21.4 Multimer technologies ………………………31.5 Antigen-specific cytotoxic T cells……………51.6 Rationale of the study ………………………………………………………………61.7 The aim of the study…………………………………………………………………72. Material and Methods ………………………………………………………………92.1 Material ………………………………………92.1.