Stochastic dynamics of cell adhesion in hydrodynamic flow [Elektronische Ressource] / von Christian Korn

Stochastic dynamicsof cell adhesionin hydrodynamic o wDissertationzur Erlangung des akademischen Grades;;doctor rerum naturalium"(Dr. rer. nat.)in der Wissenschaftsdisziplin ;;Theoretische Physik"eingereicht an derMathematisch-Naturwissenschaftlichen Fakult atder Universit at Potsdamangefertigt amMax-Planck-Institut fur Kolloid- und Grenz achenforschung in PotsdamvonChristian Korngeboren am 05. Oktober 1976 in TubingenPotsdam, im Januar 2007AbstractIn this thesis the interplay between hydrodynamic transport and speci c ad-hesion is theoretically investigated. An important biological motivation forthis work is the rolling adhesion of white blood cells experimentally investi-gated in o w chambers. There, speci c adhesion is mediated by weak bondsbetween complementary molecular building blocks which are either located onthe cell surface (receptors) or attached to the bottom plate of the o w chamber(ligands).The model system under consideration is a hard sphere covered with recep-tors moving above a planar ligand-bearing wall. The motion of the sphere isin uenced by a simple shear o w, deterministic forces, and Brownian motion.An algorithm is given that allows to numerically simulate this motion as wellas the formation and rupture of bonds between receptors and ligands. Thepresented algorithm spatially resolves receptors and ligands.