Species specific aspects of ecdysteroid receptor response to ecdysteroids and juvenile hormone [Elektronische Ressource] / vorgelegt von Joshua M. Beatty

Species specific aspects of ecdysteroid receptor response to ecdysteroids and juvenile hormone Dissertation zur Erlangung des Doktorgrades Dr. rer. nat. der Fakultät für Naturwissenschaften an der Universität Ulm vorgelegt von Joshua M Beatty aus Sherrills Ford NC USA 2011 Amtierender Dekan der Fakultät für Naturwissenschaften der Universität Ulm: Prof. Dr. Axel Groß Erstgutachterin: Prof. Dr. Margarethe Spindler-Barth Zweitgutachter: Prof. Dr. Wolfgang Weidemann Tag der Promotion: 10.06.2011 Table of contents Table of Contents Introduction .......................................................................................................................................... 5 The functional ecdysteroid receptor ... 5 EcR isoforms in Drosophila melanogaster ......................................................................................... 5 Ultraspiracle (USP) in Drosophila melanogaster ................ 7 Similarities of EcR and USP across two insect species ..................................................................... 8 The Ecdysone and juvenile hormone interaction ............... 8 Ecdysone agonists ............................................................................................. 9 Motivation and specific aims of this work ......................................................... 10 Functional analysis of the Drosophila melanogaster USP LBD ...............