Simulation of radiation effects using biomathematical models of the megakaryocytic cell renewal system [Elektronische Ressource] / Dieter Hans Gräßle

Arbeitsgruppe fur Strahlenmedizininische ForschungundWHO-Kollaborationszentrum fur Strahlenunfallmanagementan derUniversitat UlmLeiter: Prof. (em.) Dr. med. Dr. hc. mult. T.M. FliednerSimulation of Radiation E ectsUsing Biomathematical Models of theMegakaryocytic Cell Renewal SystemDissertation zur Erlangung des Doktorgrades der Humanbiologieder Medizinischen Fakultat der Universitat Ulm Vorgelegt vonDieter Hans Gra leaus Lauingen an der Donau2000Amtierender Dekan: Prof. Peter Gierschik1. Berichterstatter: Prof. Theodor M. Fliedner2. Berich Prof. H. Wol Tag der Promotion: 14.07.2000Contents1 Introduction and Overview 11.1 Interaction of Mathematics and Biomedical Research . . . . . . . . . . 11.2 Biomathematical Models and Hematopoietic Radiation E ects . . . . . 31.3 Objectives of the Presented Thesis . . . . . . . . . . . . . . . . . . . . 41.4 Overview on the Thesis . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 Material and Methods 72.1 Biological and Radiological Aspects . . . . . . . . . . . . . . . . . . . . 82.2 Data on Irradiation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 212.3 Mathematical Techniques and Methods . . . . . . . . . . . . . . . . . . 232.4 Computer Science and Data Processing . . . . . . . . . . . . . . . . . . 513 Results 533.1 Modeling Thrombocytopoiesis in Rodents . . . . . . . . . . . . . . . . 553.2 Model Based Analysis of the Hematological E ects of Acute Irradiation 893.