Signaling through the erythropoietin receptor is promoted by dense packing of the transmembrane domain and regulated by rapid receptor internalization [Elektronische Ressource] / presented by Verena Becker

Dissertationsubmitted to theCombined Faculties for the Natural Sciences and for Mathematicsof the Ruperto-Carola University of Heidelberg, Germanyfor the degree ofDoctor of Natural Sciencespresented byDipl.-Biol. Verena Beckerborn in Lennestadt, Germanyoral examination: May 3, 2007Signaling through the Erythropoietin Receptor is Promoted byDense Packing of the Transmembrane Domainand Regulated by Rapid Receptor InternalizationReferees: PD. Dr. Ursula KlingmüllerProf. Dr. Bernhard DobbersteinAcknowledgements 3Many thanks to all the people who supported me during my work.First of all, I am grateful to my supervisor PD Dr. Ursula Klingmüller for her advice andguidance, for the time and effort she spent on my behalf, and for giving the opportunity towork in her lab. Her continuous support and enthusiasm encouraged and motivated me.I thank Prof. Dr. Bernhard Dobberstein for being the second referee for this thesis.Many thanks to all current and former members of the lab for their support, for the niceatmosphere and the cheerful time we spent inside and outside the lab. I would like to thankUte Baumann for providing such great help. Many thanks to Dr. Andrea C. Pfeifer for heradvice on fluorescence microscopy and counsel as a member of my PhD committee. I amgrateful to Marcel Schilling and Julie Bachmann for contributing to the endocytosis project.I would like to acknowledge the people being part of fruitful collaborations. Prof. Dr.