Signaling events at the {β-selection [beta-selection] checkpoint during thymocyte development [Elektronische Ressource] / von Marei Dose

Signaling events at the β-selection checkpointduring thymocyte developmentVon der Naturwissenschaftlichen Fakultätder Gottfried Wilhelm Leibniz Universität Hannoverzur Erlangung des GradesDoktorin der NaturwissenschaftenDr. rer. nat.genehmigte DissertationvonDipl.-Biochem. Marei Dosegeboren am 15.02.1979, in Preetz, Holst2007Referent: Prof. Dr. Walter MüllerKorreferentin: Fotini Gounari, PhD, H.D.R.Tag der Promotion: 23. Mai 2007Table of Contents 3Table of contents1 ZUSAMMENFASSUNG .................................................................................... 72 ABSTRACT .................................................................................................... 103 INTRODUCTION............................................................................................. 133.1 The thymus.................................................................................................................................................... 143.2 Getting there- extrathymic precursors in bone marrow and blood ...................................................... 163.3 Inside the thymus- stages of T cell development...................................................................................... 203.4 Migration of developing thymocytes ......................................................................................................... 233.5 The preTCR........................................................................................