Sequence based methods for the prediction and analysis of the structural topology of transmembrane beta barrel proteins [Elektronische Ressource] / von Sikander Hayat

Sequence based methods for the prediction andanalysis of the structural topology oftransmembrane beta barrel proteinsDissertationzur Erlangung des Gradesdes Doktors der Naturwissenschaftender Naturwissenschaftlich-Technischen Fakult¨at IIIChemie, Pharmazie, Bio- und Werkstoffwissenschaftender Universit¨at des SaarlandesvonSikander HayatSaarbru¨cken31. M¨arz 2010Tag des Kolloquiums: .................................Dekan: .................................Berichterstatter: ...................................................................................................Vorsitz: .................................Akad. Mitarbeiter: .................................2AcknowledgementsFirst and foremost, I am grateful to my supervisor Prof. Dr. Volkhard Helmsfor providing me with the opportunity to work in his research group. My workwould not have been possible without his constant guidance, suggestions andsupport. I am also thankful to the Graduiertenkolleg 1276/1 of the DFG forprovidingmewithanactivescientificenvironmentandsustainingmyworkwitha generous fellowship. I would also like to thank the center for bioinformaticsat the Saarland University.I want to thank the ”Coffee-club” for fun times in the afternoon breaks andmy colleagues at the research group for a pleasant working atmosphere. I amespeciallythankfultoMazenAhmadforlivelyandfruitfuldiscussions. Iamalsograteful to Tiham´er Geyer for his invaluable technical help with the computersystems.