Senescent BALB-c mice are able to develop resistance to Leishmania major infection [Elektronische Ressource] / vorgelegt von Mihaela Anca Sindrilaru

Universität Ulm Abteilung Dermatologie Abteilungsleiter: Prof. Dr. Karin Scharffetter-Kochanek Senescent BALB/c mice are able to develop resistance to Leishmania major infection Dissertation zur Erlangung des Doktorgrades der Medizin der medizinischen Fakultät der Universität Ulm vorgelegt von Mihaela Anca Sindrilaru geb. in Medias, Rumänien Ulm, 2005I Amtierender Dekan: Prof Dr. K.M. Debatin 1. Berichterstatter: Prof. Dr. C. Sunderkötter 2. Berichterstatter: Prof. Dr. K.D. Fischer Tag der Promotion: 29.06.2006 IITABLE OF CONTENTS 1. INTRODUCTION……………………………………………………………………….1 1.1. Leishmaniasis …………………………………………………………………………....1 1.1.1. The parasite ……………………………………………………………………1 1.1.2. Life cycle 1.1.3. Epidemiology ……………………………………………………………………2 1.1.4. Clinical forms in humans …………………………………………………….3 1.1.5. Experimental leishmaniasis in mice …………………………………………….5 1.1.6. Immunity to infection with Leishmania major …………………………….6 1.1.7. Immune response and disease progression in inbread resistant strains ..……7 1.1.8. Immune response and disease progression in inbread susceptible strains ……..8 1.2. The immune response in senescence …………………………………………………….9 1.2.1. The innate immunity …………………………………………………………….9 1.2.2. T cell response alterations in senescence ……………………………………10 1.3. Aims …………………………………………………………………………………...12 2. MATERIALS AND METHODS …………………………………………………....13 2.1.