Screening the cell adhesion activity of muscle skeletal progenitor cells on defined nanopatterns [Elektronische Ressource] / presented by Carlos Alberto Hung Low

Dissertationsubmitted to theCombined Faculties for the Natural Sciences and for Mathematicsof the Ruprecht Karl University of Heidelberg, Germany,for the degree ofDoctor of Natural Sciences (Dr. rer. nat.)Presented byMSc. Molecular Bioengineering Carlos Alberto Hung LowBorn in Caracas, VenezuelathOral examination: November 16 , 2010Screening the cell adhesion activity ofmuscle skeletal progenitor cells ondefined nanopatternsReferees:Prof. Thomas HolsteinProf. Joachim P. SpatzTo my motherContentsSymbols and abbreviations vSummary of the thesis viiZusammenfassung der Dissertation xi1 Introduction 11.1 Elucidating cellular environments . . . . . . . . . . . . . . . . . . . . 11.2 Aims . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 Literature review 52.1 The extra cellular matrix (ECM) . . . . . . . . . . . . . . . . . . . . 52.1.1 Collagens . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62.1.2 Fibronectin . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62.1.3 Laminin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72.1.4 Tenascin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82.1.5 Proteoglycans . . . . . . . . . . . . . . . . . . . . . . . . . . . 92.1.6 Fibrinogen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92.2 Cell cytoskeleton and focal adhesion (FA) signalling . . . . . . . . . . 102.2.1 Integrins and other receptors systems . . . . . . . . . . . . . .