OncoLogic™ Quick Start Tutorial

OncoLogic ™Quick Start TutorialA Step-by-Step Guide to Using OncoLogic ™ to Predict Potential CarcinogenicityOncoLogic ™ – How it Works• Designed to mimic the thinking and reasoning of human experts • Uses knowledge-based rules for chemical classes to predict cancer concern • Evaluates how substituents on the chemical may affect carcinogenicity – Concern level changes accordingly • Assigns a baseline concern level rangingfrom low to high 2 Concern LevelsDefinition OncoLogic ™ Concern Low Unlikely to be carcinogenic Likely to have equivocal carcinogenic Marginal activity Low – Moderate Likely to be weakly carcinogenic Likely to be a moderately active Moderate carcinogen Highly likely to be a moderately active Moderate – High carcinogen 3High Highly likely to be a potent carcinogen OncoLogic ™ – How it Works• Two separate methods are used to predict potential carcinogenicity – SAR analysis (i.e., structural analysis) – Functional analysis 4 SAR Analysis • OncoLogic ™ uses mechanism-based SAR analysis to predict potential carcinogenicity • Analysis is based upon knowledge of the structural and biological bases ofcarcinogenicity of various classes of chemicalcarcinogens • Incorporates knowledge-based rules and chemical-specific user input • Rules were developed jointly by cancer experts and system development experts based oncancer studies and scientific publications 5 Functional Analysis • Integrates the ...