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11 Environmental Health Criteria XXX 2 PRINCIPLES FOR MODELLING DOSE-RESPONSE FOR THE RISK 3 ASSESSMENT OF CHEMICALS 4 5 6 7 8 9 10 11 DRAFT 12 13 14 15 16 17 18 19 Prepared by the 20 21 22 WHO TASK GROUP ON ENVIRONMENTAL HEALTH CRITERIA FOR PRINCIPLES FOR 23 MODELLING DOSE-RESPONSE FOR THE RISK ASSESSMENT OF CHEMICALS 24 25 26 International Programme on Chemical Safety 27 World Health Organization 28 Geneva 29 30 31 32 33 34 35 36 37 38 39 40 41 42 February 2004 21 TABLE OF CONTENTS 2 3 FOREWORD 4 5 LIST OF MEMBERS OF WHO PLANNING GROUP FOR IPCS HARMONIZATION 6 PROJECT ON DOSE-RESPONSE MODELLING 7 8 LIST OF MEMBERS OF WHO TASK GROUP ON ENVIRONMENTAL HEALTH 9 CRITERIA FOR PRINCIPLES FOR MODELLING DOSE-RESPONSE FOR THE RISK 10 ASSESSMENT OF CHEMICALS 11 12 LIST OF OTHER CONTRIBUTORS 13 14 LIST OF SECRETARIAT 15 16 LIST OF ACRONYMS AND ABBREVIATIONS 17 18 1. INTRODUCTION, EXECUTIVE SUMMARY AND RECOMMENDATIONS 19 1.1 Introduction 20 1.1.1 Intended Audience 21 1.1.2 Scope 22 1.2. Executive Summary 23 1.3 Conclusions and Recommendations 24 1.3.1 Conclusions 25 1.3.2 Recommendations 26 27 2. RISK ANALYSIS 28 2.1 Decision Paradigms 29 2.2 Risk Analysis Paradigms 30 2.3 Motivations and Considerations for Producing a Formal Risk Assessment 31 2.3.1 Transparency and Justification 32 2.3.2 Public Health and Individual Health 33 2.3.3 ...