Roller compaction of pharmaceutical ingredients [Elektronische Ressource] : on the understanding of the compaction and the use of knowledge based applications in the formulation of tablets / presented by Andrés-Miguel Miguélez-Morán

Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Andrés-Miguel Miguélez-Morán, Lic. Pharm. born in Esplugues de Llobregat, Spain thOral-examination: 30 April 2009 ROLLER COMPACTION OF PHARMACEUTICAL INGREDIENTS ON THE UNDERSTANDING OF THE COMPACTION AND THE USE OF KNOWLEDGE BASED APPLICATIONS IN THE FORMULATION OF TABLETS Referees: Prof. Dr. Gert Fricker Priv. Doz. Dr. Ulrich Massing The following work has been carried out at the Dept. of Pharmaceutical Technology and Biopharmacy of the Institute of Pharmacy and Molecular Biotechnology of the University of Heidelberg (Germany), and at the School of Chemical Engineering of the University of Birmingham. First of all, I would like to thank Prof. Dr. Fricker for accepting me as a doctorate student at the institute, for allowing me to perform the major part of the experimental of this work, and for agreeing to be my supervisor and my referee. I also would like to express my thanks Dr. Massing, for kindly agreeing to be my second referee. Moreover, I would like to acknowledge Prof. Dr. Hilgenfeldt and Prof. Dr. Reichling, for being part of the committee in this viva examination.