Role of the soluble epoxide hydrolase and cytochrome P450-derived epoxyeicosatrienoic acids in hypoxic pulmonary vasoconstriction and hypoxia induced pulmonary vascular remodelling [Elektronische Ressource] / von Benjamin Keserü

Role of the soluble epoxide hydrolase and cytochrome P450-derived epoxyeicosatrienoic acids in hypoxic pulmonary vasoconstriction and hypoxia-induced pulmonary vascular remodelling Dissertation zur Erlangung des Doktorgrades der Naturwissenschaften vorgelegt beim Fachbereich Biochemie, Chemie und Pharmazie der Goethe-Universität in Frankfurt am Main von Benjamin Keserü aus Aalen Frankfurt 2008 vom Fachbereich Biochemie, Chemie und Pharmazie der Goethe-Universität als Dissertation angenommen Dekan: Prof. Dr. Harald Schwalbe Gutachter: Prof. Dr. Ingrid Fleming Prof. Dr. Dieter Steinhilber Datum der Disputation: Parts of this work have been published online: Keserü B, Barbosa-Sicard E, Popp R, Fisslthaler B, Dietrich A, Gudermann T, Hammock BD, Falck JR, Weissmann N, Busse R, Fleming I. Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response. FASEB J 2008. To Gila Table of Contents Table of contents Table of contents.......................................................................................................1 1. Introduction.....................................................................................................3 1.1. Hypoxic pulmonary vasoconstriction............................................