Role of the {MID1/α4 [MID1 alpha4] protein complex in Huntington's disease [Elektronische Ressource] / vorgelegt von Ewa Jastrzebska

Role of the MID1/ α4 protein complex in Hunt ingto n’ s disease Dissertation zur Erlangung des akademischen Grades des Doktors der Naturwissenschaften (Dr. rer. nat.) eingereicht im Fachbereich Biologie, Chemie, Pharmazie der Freien Universität Berlin vorgelegt von Ewa Jastrzebska aus Wroclaw, Polen Berlin, Februar, 2010 Role of the MID1/ α4 protein complex in Hunt ingto n’ s disease A thesis submitted in conformity with the requirements for the degree of Dr. rer. nat. submitted to the Department of Biology, Chemistry and Pharmacy of the Freie Universität Berlin submitted by Ewa Jastrzebska from Wroclaw, Poland Berlin, February, 2010 1. Gutachter: Prof. Dr. Constance Scharff (Institut für Biologie, Fachbereich Biologie, Chemie, Pharmazie, Freie Universität Berlin) 2. Gutachter: Prof. Dr. Susann Schweiger (Division of Pathology and Neuroscience, University of Dundee; Max-Planck-Institut für Molekulare Genetik) Disputation am 20.05.2010 Table of Contents Table of contents 1. INTRODUCTION ______________________________________________________ 5 1.1 Huntington’s disease (HD) _____________ 5 1.1.1 Clinical features of Huntington‟s disease _________________________________ 7 1.1.2 Genetics of Huntington‟s disease _______ 7 1.1.