Role of SOCS proteins in FLT3-ITD and BCR-ABL mediated leukemogenesis [Elektronische Ressource] / by Pavan Kumar Reddy, N. G.

Lack of cytokine controlPavan Kumar Reddy, N.GRole of SOCS proteins in FLT3-ITD and BCR/ABL mediated leukemogenesisSOCS1 cooperates with FLT3-ITD by promoting the escape from external cytokine control2010 Role of SOCS proteins in FLT3-ITD and BCR/ABL mediated leukemogenesis Dissertation to obtain the Degree of Doctor of Philosophy at the Faculty of Natural Sciences Submitted to the Faculty of Biochemistry, Chemistry and Pharmacy of the Goethe University in Frankfurt am Main by Pavan Kumar Reddy, N.G. From Vepakunta, India. Frankfurt am Main, 2010 (D30) Submitted to the Faculty of Biochemistry, Chemistry and Pharmacy of the Goethe University in Frankfurt am Main Dean: Prof. Dr. Dieter Steinhilber Examiners: 1. Prof. Dr. Rolf Marschalek 2. Prof. Dr. Hubert Serve Date: 24-11-2010 Table of Contents Table of Contents Table of Contents ................................................................................ iii Summary ............................. vii Zusammenfassung .............. ix 1 Introduction ...................................................................................... 1 1.1 Hematopoiesis ............................. 1 1.2 Leukemia ...................................... 2 1.2.1 Acute myeloid leukemia (AML) .......................................... 3 1.2.2 Acute lymphoblastic leukemia (ALL) ................................... 3 1.