Role of {PI3Kβ [PI3K beta] and {PI3Kγ [PI3K gamma] isoforms in sphingosine 1-phosphate (S1P) induced endothelial cell migration [Elektronische Ressource] / von Qing Chang

Role of PI3Kβ and PI3Kγ Isoforms in Sphingosine 1-Phosphate (S1P)-Induced Endothelial Cell Migration Dissertation zur Erlangung des akademischen Grades doctor rerum naturalium vorgelegt dem Rat der Biologisch-Pharmazeutischen Fakultät der Friedrich-Schiller- Universität Jena von Qing Chang geboren am 06. 11. 1975 in Beijing (VR China) Gutachter: 1. 2. 3. 4. Content Content 1. INTRODUCTION........................................................................................................................... 1 1.1 PHOSPHOINOSITIDE 3-KINASES (PI3KS) ....................................................................................... 1 1.1.1 Class I PI3Ks ........................................................................................................................... 1 1.1.2 Class II and III PI3Ks.............................................................................................................. 6 1.2 SIGNALLING REACTIONS OF PI3-KINASES..................................................................................... 7 1.2.1 Akt/PKB .................................................................................................................................. 7 1.2.2 Rho GTPases............................................................................................................................ 9 1.