Role of phosphoinositide-3-kinase (PI3K), Akt signaling in apoptosis regulation of neuroectodermal tumors [Elektronische Ressource] / Daniela Opel

University Children’s Hospital Prof. Dr. K.-M. Debatin Role of phosphoinositide-3-kinase (PI3K)/Akt signaling in apoptosis regulation of neuroectodermal tumors Dissertation zur Erlangung des Doktorgrades der Humanbiologie der Medizinischen Fakultät der Universität Ulm Daniela Opel geb. in Herzberg/Elster 2008 Amtierender Dekan: Prof. Dr. Klaus-Michael Debatin 1. Berichterstatter: Prof. Dr. Simone Fulda 2. Berichterstatter: Prof. Dr. Thomas Seufferlein Tag der Promotion: 09. Mai 2008 Meinem Mann und meinem Sohn Table of contents i Table of contents................................................................................................................... i Abbreviations............................................................................................................................................. iii 1 Introduction ...................................................................................................................... 1 1.1 Cancer.......................................................................................................................... 1 1.2 Neuroectodermal tumors ............................................................................................. 3 1.2.1 Glioblastoma – a brain tumor............................................................