Role of NO-cGMP signalling pathway in mediation of ischemia-reperfusion lung injury [Elektronische Ressource] / by Bakytbek Egemnazarov

Role of NO-cGMP signalling pathway in mediation of ischemia-reperfusion lung injury Inaugural Dissertation submitted to the Faculty of Medicine in partial fulfilment of the requirements for the PhD-Degree of the Faculty of Medicine of the Justus Liebig University Giessen by Bakytbek Egemnazarov of Bishkek, Kyrgyz Republic Giessen 2008 From the Medical Clinic II, University of Giessen Lung Centre Chairman: Werner Seeger, Prof., M.D. of the Faculty of Medicine of the Justus Liebig University Giessen First Supervisor and Committee Member: Second Supervisor and Committee Member: Committee Members: Date of Doctoral Defence: Role of NO-cGMP signalling pathway in mediation of ischemia-reperfusion lung injury Inaugural Dissertation submitted to the Faculty of Medicine in partial fulfilment of the requirements for the PhD-Degree of the Faculty of Medicine of the Justus Liebig University Giessen by Bakytbek Egemnazarov of Bishkek, Kyrgyz Republic Giessen 2008 INDEX OF CONTENTS 1 INTRODUCTION ...........................................................................................................1 1.1 Ischemia/reperfusion injury. Definition. ..................................................................1 1.2 Role of NO-cGMP signalling pathway in I/R injury ................................................1 1.2.1 Role of iNOS in I/R injury........