Role of lysophospholipids in the biological activity of NK cells [Elektronische Ressource] / submitted by Mariana Lgadari

Friedrich-Schiller University of Jena Medical Faculty Department of Dermatology “Role of lysophospholipids in the biological activity of NK cells” Dissertation For the obtainment of the academic degree doctor rerum naturalium (Dr. rer. nat.) Presented to the Council of the Faculty of Biology and Pharmacy of the Friedrich-Schiller University of Jena Submitted by Mariana Lagadari thborn on August 17 1977, in Concordia, Argentina Jena, 2008 Guthachter: 1. Prof. Dr. R. Wetzker 2. Prof. Dr. J. Norgauer 3. Prof. Dr. R. Jessberger Tag der Doktorprüfung: 22.09.08 Tag der öffentlichen Verteidigung: 22.09.08 Index 3 Index Abreviatons 6 Summary 8 Zusamenfasung 10 1. Introduction 12 1.1. Immune System 2 1.1.1. Innate Immune Response 12 1.1.2. Adaptive Immune 13 1.2. Natural Killer Cells 14 1.2.1. Background 14 1.2.2. NK cell receptors 16 1.2.2.1. NK inhibiting receptor 17 1.2.2.2. activating 18 1.2.3. The mechanism of NK functions 20 1.2.3.1. Cytotoxic activity 21 1.2.3.2. Cytokine Secretion 23 1.3. Chemotaxins and NK cells 24 1.3.1. Chemokines NK 1.3.2. Lysophospholipids 28 1.4 Tumor cels 29 1.4.1. Tumor microenvironment 29 1.4.2. Melanoma tumor cells 32 1.4.3.