Role of enzymatically modified low-density lipoprotein (E-LDL) on macrophage gene expression [Elektronische Ressource] / vorgelegt von Quoc Chinh, Duong

ROLE OF ENZYMATICALLY MODIFIED LOW-DENSITY LIPOPROTEIN (E-LDL) ON MACROPHAGE GENE EXPRESSION DISSERTATION ZUR ERLANGUNG DES DOKTORGRADES DER NATURWISSENSCHAFTEN (DR.RER.NAT.) DER NATURWISSENSCHAFTLICHEN FAKULTÄT III – BIOLOGIE UND VORKLINISHCE MEDIZINE DER UNIVERSITÄT REGENSBURG vorgelegt von Quoc Chinh, Duong Regensburg, Juli 2007 All the experimental works have been carried out at the Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg under the direction of Prof. Dr. Gerd Schmitz. Submission date: 17.07.2007 Board of examiners: Prof. Dr. Herbert Tschochner (chairman) stProf. Dr. Egghard Holler (1 . supervisor) ndProf. PD. Dr. Charalampos Aslanidis (2 . supervisor) rdProf. Dr. Stephan Schneuwly (3 . examiner) Prof. Dr. Richard Warth (add. examiner) Table of contents Page Acknowledgment i Summary (English/Deutsch) ii 1 INTRODUCTION 1 1.1. ROLE OF MONOCYTES AND MACROPHAGES IN ATHEROSCLEROSIS 1 1.2. ENZYMATIC MODIFICATION OF LOW-DENSITY LIPOPROTEIN 3 1.3. BIOCHEMISTRY, CELL ORGANELLE DISTRIBUTION AND REGULATION OF PHOSPHOLIPID PATHWAYS 3 1.4. THE ROLE OF BIOLOGICALLY ACTIVE DERIVATIVES OF THE GLYCERO-PHOSPHOLIPID AND AMINOPHOSPHOLIPID PATHWAYS 6 1.4.1. Biological role of lysophosphatidylcholine 6 1.4.2. Biological role of lysophosphatidic acid 8 1.4.3. Biological role of ceramide 10 1.5.4.