Role of Ame1, a central component of the Saccharomyces cerevisiae kinetochore, in kinetochore function and structure [Elektronische Ressource] / presented by Astrid Schäfer

Role of Ame1, a central component of the Saccharomyces cerevisiae kinetochore, in kinetochore function and structure Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Science Presented by Astrid Schäfer The beginning of knowledge is the discovery of something we do not understand. Frank Herbert Role of Ame1, a central component of the Saccharomyces cerevisiae kinetochore, in kinetochore function and structure Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Science Presented by Diplom-Biochemist Astrid Schäfer Referees: Prof. Dr. Felix Wieland PD Dr. Johannes Lechner Date of oral examination: 18.10.2006 TABLE OF CONTENTS I Table of contents I-IV Abbreviations V SUMMARY 1 ZUSAMMENFASSUNG 3 1. INTRODUCTION 5 1.1 The S. cerevisiae cell cycle – getting in and out of mitosis 6 1.