Role and regulation of the heat shock proteins {Hsp90α [Hsp90alpha] and β [beta] in multiple myeloma [Elektronische Ressource] / vonSarika Jain

Role and regulation of the heat shock proteins Hsp90 α and β in Multiple Myeloma Dissertation zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) im Fach Biologie eingereicht an der Mathematisch-Naturwissenschaftlichen Fakultät I der Humboldt-Universität zu Berlin von Sarika Jain, B.Sc., M.Sc. 24.01.1979, New Delhi INDIA Präsident der Humboldt-Universität zu Berlin Prof. Dr. Christoph Markschies Dekan der Mathematisch-Naturwissenschaftlichen Fakultät I Prof. Dr. Christian Limberg Gutachter: 1. Prof. Harald Saumweber 2. Prof. Wolfgang Uckert 3. Dr. Ralf C. Bargou Tag der mündlichen Prüfung: 06. 12. 2007 DECLARATION I hereby certify that the thesis entitled ‘Role and regulation of the heat shock proteins Hsp90 and in multiple myeloma’ submitted to MDC/HUB for the fullfillment of the Ph.D. degree, embodies the original research work. The microarray gene chip experiment was performed in cooperation with Dr. Ute Ungethüm and Dr. Ralf-Jürgen Kuban from the Laboratory of Functional Genomics, Charité, University Medicine Berlin, Germany and immunohistochemical analyses was performed in cooperation with Dr. Mindaugas Andrulis from the Institute of Pathology, University Hospital of Würzburg, Germany (current address Institute of Pathology, University Hospital of Heidelberg, Germany).