Respiration of mitochondria in living organisms is controlled by the ATP-ADP ratio and phosphorylation pattern of cytochrome c oxidase [Elektronische Ressource] / by Rabia Ramzan

Respiration of mitochondria in living organisms is controlled by the ATP/ADP ratio and phosphorylation pattern of cytochrome c oxidase Dissertation For the doctor’s degree of natural sciences (Dr. rer. nat., corresponding to Ph.D.) submitted to the Fachbereich Chemie Philipps-Universität Marburg by Rabia Ramzan From Lahore, The Islamic Republic of Pakistan Marburg/Lahn 2010 The presented dissertation was performed from August 2007-July 2010 under the supervision of Prof. Dr. Bernhard Kadenbach, Fachbereich Chemie, in the Heart Surgery laboratory of Prof. Dr. Sebastian Vogt at the Biomedical Research Center, Philipps-Universität Marburg. Vom Fachbereich Chemie, Philipps-Universität Marburg als Dissertation angenomen am: Erstgutachter: Prof. Dr. Bernhard Kadenbach Zweitgutachter: Prof. Dr. Lars Essen Tag der Disputation am: 12. 07. 2010 Some of the results of this dissertation are published: 1. Helling, S. Vogt, S. Rhiel, A. Ramzan, R. Wen, L. Marcus, K, Kadenbach, B. Phosphorylation and kinetics of mammalian cytochrome c oxidase, Mol. Cell. Proteomics, 7 (2008) 1714-1724. 2. Kadenbach, B., Ramzan, R., Vogt, S. Degenerative diseases, oxidative stress and cytochrome c oxidase function, Trends Mol. Med. 15 (2009) 139-147. 3. Kadenbach, B., Ramzan, R., Wen, L., Vogt, S. New extension of the Mitchell Theory for oxidative phosphorylation in mitochondria of living organisms, Biochim. Biophys.