Regulational expression of the CD28-related costimulatory molecule ICOS in multiple sclerosis [Elektronische Ressource] : implications for the role of costimulation in autoimmunity / vorgelegt von Matthias Mehling

Aus dem Zentrum für Neurologie der Universität TübingenAbteilung Allgemeine NeurologieÄrztlicher Direktor: Professor Dr. M. WellerRegulational expression of the CD28-relatedcostimulatory molecule ICOS in Multiple Sclerosis:implications for the role of costimulation inautoimmunityInaugural-Dissertationzur Erlangung des Doktorgradesder Medizinder Medizinischen Fakultätder Eberhard Karls Universitätzu Tübingenvorgelegt vonMatthias MehlingausEichstätt20052Dekan: Professor Dr. Claus D. Claussen1. Berichterstatter: Professor Dr. Arthur Melms2. Berichterstatter: Privatdozent Dr. P. Brossart31 Introduction: _____________________________________________________71.1 T cell mediated immune response _______________________________71.2 The role of costimulation in T cell activation_________________________71.3 The family of B7/CD28 costimulatory molecules _____________________81.4 ICOS - ICOSL interactions_____________________________________131.4.1 Structure and regulational expression of ICOS __________________131.4.2 Functional aspects of ICOS engagement ______________________141.5 Multiple Sclerosis: clinical, epidemiological and immunepathogeneticcharacteristics ______________________________________________141.6 The role of costimulation in Multiple Sclerosis pathogenesis ___________162 Aim of the Study _________________________________________________193 Material and Methods _____________________________________________203.