Regulation of the hypoxia inducible factor-1 by prolonged and severe low oxygen tension [Elektronische Ressource] / vorgelegt von Tobias Schmid

Regulation of the Hypoxia-Inducible Factor-1 by Prolonged and Severe Low Oxygen Tension Dem Fachbereich Biologie der Technischen Universität Kaiserslautern zur Erlangung des akademischen Grades Doktor der Naturwissenschaften (Dr. rer. nat.) eingereichte Dissertation vorgelegt von Tobias Schmid Betreuer: Prof. Dr. Bernhard Brüne Kaiserslautern, im August 2004 Vorsitzender der Prüfungskommision: Prof. Dr. Dr. Heinrich Zankl 1. Gutachter: Prof. Dr. Bernhard Brüne 2. Gutachter: Prof. Dr. Thomas Kietzmann “Love is like oxygen. You get too much you get too high, not enough and you're gonna die.” (The Sweet, 1978) Acknowledgements After an enormously interesting, difficult, enjoyable, exhausting, exciting, and also sometimes frustrating 3 years, there are a lot of people whom I want to thank for being with me and supporting me in many different ways during that time. Before I begin, I want to apologize to all the people I have unintentionally forgotten to mention in the following. After weeks of writing, my brain seems to be a little drained. So please forgive me and feel included. First of all, I want to thank my supervisor Prof. Bernhard Brüne for offering me the opportunity of working on my Ph.D. thesis in his labs, first in Erlangen and then in Kaiserslautern. His discussions and support greatly facilitated my work, as, of course, did his financial support.