Regulation of phosphodiesterases by profibrotic regulators [Elektronische Ressource] / by Kolosionek, Ewa Julia

Regulation of Phosphodiesterases by profibrotic regulators Inaugural Dissertation submitted to the Faculty of Medicine in partial fulfillment of the requirements for the PhD-Degree of the Faculties of Veterinary Medicine and Medicine of the Justus Liebig University Giessen by Kolosionek, Ewa Julia of Wroclaw, Poland Giessen 2008 From the Department of Medicine Director / Chairman: Prof. Dr. Werner Seeger of Medicine of the Justus Liebig University Giessen First Supervisor and Committee Member: Second Supervisor and Committee Member: Committee Members: Date of Doctoral Defense: Table of context ________________________________________________________________________ I. Table of context I. Table of context I II. List of Figures IV III. List of Tables VI IV. List of abbreviations VII V. Summary IX VI. Zusammenfassung XI 1 1.Introduction 1 1.1 Epithelial to mesenchymal transition 1 1.1.1 Characteristic of epithelial to mesenchymal transition 1 1.1.2 Induction of EMT 3 1.1.3 TGF-β and its role during EMT 3 1.1.4 EMT in embryo and adults 5 1.1.4.1 EMT in development 5 1.1.4.2 EMT in wound healing 5 1.1.4.3 EMT in cancer 5 1.1.4.4 EMT in fibrosis 6 1.2 Phosphodiesterases 7 1.2.1 Nomenclature of Phosphodiesterases 7 1.2.2 Classification of Phosphodiesterases 7 1.2.2.1 cGMP 7 1.2.2.2 cAMP 8 1.2.3 Structure of Phosphodiesterases 10 1.2.