Regulation of morphogenetic cell behavior by xenopus paraxial protocadherin [Elektronische Ressource] / presented by Corinna D. Berger

Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Diplom-Biologin Corinna D. Berger born in Heidelberg, Germany Oral-examination:................................................ Regulation of Morphogenetic Cell Behavior by Xenopus Paraxial Protocadherin Referees: Prof. Dr. Herbert Steinbeisser Prof. Dr. Jörg Großhans Table of Contents I Table of Contents 1 Summary ______________________________________________________________ 1 2 Introduction ___________________________ 3 2.1 Gastrulation _______________________________3 2.2 Convergent extension movements_____________________________________________4 2.3 Tissue separation ___________________________6 2.4 Regulators of convergent extension and tissue separation _________________________7 2.4.1 Wnt-pathways ________________________________________________________________ 7 2.4.2 Cadherins ___ 11 2.5 Aim of this study 19 3 Results _______________________________________________________________ 20 3.1 PAPC has signaling properties_______________________________________________ 20 3.1.1 Rho activity in the dorsal mesoderm depends on PAPC function ________________________ 20 3.1.2 PAPC and Spry interact independently of FGF-signaling 23 3.1.