Radiochemical aspects of production and processing of radiometals for preparation of metalloradiopharmaceuticals [Elektronische Ressource] / vorgelegt von Konstantin P. Zhernosekov

Radiochemical Aspects of Production and Processing of Radiometals for Preparation of Metalloradiopharmaceuticals Dissertation zur Erlangung des Grades „Doktor der Naturwissenschaften“ am Fachbereich Chemie, Pharmazie und Geowissenschaften der Johannes Gutenberg-Universität Mainz vorgelegt von Konstantin P. Zhernosekov geboren in Morozova, Russland Mainz 2006 To My Family Table of Contents Abstract 6 1. Introduction 8 1.1. Nuclear medical state-of-the-art concepts/ Radionuclides of choice 9 1.1.1. Single photon emission tomography 9 1.1.2. Positron emission tomography 11 1.1.3. Radionuclide therapy 12 1.2. (non-Tc, non-Re) Metalloradiopharmaceuticals 16 1.2.1. Specific activity of metalloradiopharmaceuticals 19 1.2.2. Requirements for radiometals 19 1.3. Production of radionuclides 21 1.3.1. Accelerator produced radiometals 21 1.3.2. Radiometals produced at nuclear reactors 22 1.3.3. Radionuclide generators 24 2. Problem and Methods 29 683. Processing of the generator produced Ga for medical applications 32 3.1. 68 68 Ge/ Ga radionuclide generator systems 32 68 683.1.1. Ge/ Ga radionuclide generator based on TiO phase 34 2 3.1.2. State-of-the-art approaches for processing of the generator produced 37 68Ga(III) 3.1.3. Processing of Ga(III) on a cation-exchanger in hydrochloric acid-acetone media 39 3.1.3.1. Radiometals for distribution measurements 40 683.1.3.2.