Proteomic signatures of Bacillus subtilis [Elektronische Ressource] / Le Thi Tam

1 Proteomic signatures of Bacillus subtilis Dissertation in fulfilment of the academic grade doctor rerum naturalium (Dr. rer. nat.) at the Faculty of Mathematics and Natural Sciences Ernst-Moritz-Arndt-University Greifswald Le Thi Tam born on 08.01.1979 in Bacninh, Vietnam Greifswald, Germany, 2006 2 Dekan: 1. Gutachter 1: 2. Gutachter 2: 3. Gutachter 3: Tag der Promotion: 3Contents Contents 3 Abbreviations 5 Summary of thesis 7 Chapter 1: Introduction 9 1. Proteomic approachs and definition of proteomic signatures 10 2. B. subtilis as model organism for functional genomics 12 3. Proteome maps in Gram-positive bacteria 13 4. Regulation and function of stress responses 14 14 4.1. Heat shock response 4.2. Salt stress response 17 4.3. Oxidative stress response 19 4.4. Antibiotic response 21 5. Regulation and function of the starvation responses in B. subtilis 23 5.1. Glucose starvation response 24 5.2. Phosphate starvation response 26 5.3. Nitrogen starvation response 27 5.4. Tryptophan starvation response 29 5.5. The RelA-dependent stringent response 31 5.6. The CodY-dependent starvation response 32 H5.7. The σ -dependent general starvation response 32 6. Degradation of aromatic compounds in microorganism 33 7.