Proteolysis of the receptor for advanced glycation end products by matrix metalloproteinases [Elektronische Ressource] / Ling Zhang

Proteolysis of the Receptor for Advanced Glycation End Products by Matrix Metalloproteinases Dissertation Zur Erlangung des Grades Doktor der Naturwissenschaften Am Fachbereich Biologie Der Johannes Gutenberg-Universität Mainz Ling Zhang geb. am 22-10-1972 in Wuhan, China Mainz 2006 i Table of Content Table of Contents Table of Contents...................................................................................................................................ii 1. Introduction....................................................................................................................................... 1 1.1 The Aβ peptide................................................................................................................................. 1 1.1.1 Aβ peptide production and its pathologic role in Alzheimer’s disease (AD)........................... 1 1.1.2 Aβ peptide clearance from the brain .......................................................................................... 2 1.2 RAGE (receptor for advanced glycation end products) .............................................................. 4 1.2.1 Structure 4 1.2.2 Expression patterns...................................................................................................................... 5 1.2.3 Extracellular ligands and their pathophysiolologic functions.................................................. 5 1.2.