PROGINS-polymorphism in the human progesterone receptor gene: a potential genetic risk factor for prostate cancer? [Elektronische Ressource] / Christian Freund

1Baylor College of Medicine, Houston, TexasBetreuung durch: Prof. Dr. med. D. G. Kieback(jetzt: Universitäts-Frauenklinik Maastricht, Niederlande)PROGINS-polymorphism in the human progesteronereceptor gene: a potential genetic risk factor forprostate cancer ?Dissertationzur Erlangung des Doktorgrades der Medizinder Medizinischen Fakultät derUniversität UlmChristian FreundStuttgart20022Amtierender Dekan: Professor Dr. R. Marre1. Berichterstatter: Professor Dr. D. Kieback2. Berichterstatter: Professor Dr. R. HautmannTag der Promotion: 14.6.20023Table of contents:1. Introduction page 5-132. Materials & Methods page 14-203. Results page 21-234. Discussion page 24-325. Conclusion page 336. Summary page 347. References page 35-478. Acknowledgements page 484Abbreviations used:BP base pairBPH benign prostatic hyperplasiaCAT chloramphenicol acetyltransferaseDHT dihydrotestosteroneDNA deoxyribonucleic acidMRNA messenger-ribonucleic acidPCR polymerase chain reactionPROGINS progesterone receptor gene insertion in intron GPSA prostate-specific antigenPSM prostate-specific membrane antigenTUR-P transurethral resection of the prostate51. Introduction:1.1. Prostate cancer and risk factorsThe prostate gland is a fibromuscular and glandular organ lying just inferior to the bladder(see Fig.1). In the United States, prostate cancer has become the second most commonlydiagnosed cancer in men (19).