Probing the regulatory mechanisms of the actomyosin system in motile cells [Elektronische Ressource] / Eva Katharina Barbosa Pfannes. Betreuer: Carsten Beta

Probing the regulatory mechanisms of the actomyosin system in motile cells Dissertation zur Erlangung des akademischen Grades "doctor rerum naturalium" (Dr. rer. nat.) in der Wissenschaftsdisziplin "Biologische Physik" eingereicht an der Mathematisch-Naturwissenschaftlichen Fakultät der Universität Potsdam von Eva Katharina Barbosa Pfannes Potsdam, den 22.08.2011 Published online at the Institutional Repository of the University of Potsdam: URL http://opus.kobv.de/ubp/volltexte/2012/5781/ URN urn:nbn:de:kobv:517-opus-57812 http://nbn-resolving.de/urn:nbn:de:kobv:517-opus-57812 Table of contents Summary .................................................................................................................... 1 Zusammenfassung .................................................................................................... 3 1 Introduction 1.1 Dictyostelium discoideum biology ......................................................................... 6 1.2 Signaling and chemotaxis in Dictyostelium discoideum ........ 7 1.3 Cyclic AMP ............................................ 9 1.4 The actin cytoskeleton ......................................................................................... 10 1.5 Actin interacting proteins ..................................................... 12 1.5.1 DdLimE ............