Presentation of recombinant proteins in modified vaccinia virus Ankara extracellular enveloped virions [Elektronische Ressource] / vorgelegt von Andrea Meiser

Presentation of Recombinant Proteins inModified Vaccinia Virus AnkaraExtracellular Enveloped VirionsDissertationzur Erlangung des Doktorgradesan derFakultät für BiologiederLUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHENvorgelegt vonAndrea MeiserJuli 20021. Gutachter: Prof. Dr. L. Gürtler2. Gutachterin: Prof. Dr. R. Brack-WernerSondergutachterin: Dr. J. Krijnse-LockerTag der mündlichen Prüfung: 21.2.200321. SUMMARY ............................................................................................................62. INTRODUCTION....................................................................................................72.1 Historical background of vaccination .................................................................72.2 Taxonomic classification of poxviruses..............................................................82.3 Modified vaccinia virus Ankara (MVA) ...............................................................92.4 Genome of vaccinia viruses ............................................................................102.5 Life cycle of vaccinia virus...............................................................................122.5.1 Adsorption and penetration ......................................................................122.5.2 Synthesis of VV-proteins and DNA replication ..........................................142.5.3 Assembly......................................................................................