Postconditioning protects endothelial cells from apoptosis during reperfusion injury [Elektronische Ressource] : role of inhibitor of apoptosis protein 2 / by Krishnaveni Gadiraju

Postconditioning protects endothelial cells from apoptosis during reperfusion injury- Role of inhibitor of apoptosis protein 2 Inaugural Dissertation submitted to the Faculty of Medicine in partial fulfillment of the requirements for the PhD-Degree of the Faculties of Veterinary Medicine and Medicine of the Justus Liebig University Giessen by Krishnaveni Gadiraju of Hyderabad, India Giessen (2010) 1 From the Institute of Physiology Director/Chairman: Prof. Dr. K. D. Schlüter of the Faculty of Medicine of the Justus Liebig University Giessen First Supervisor and Committee Member: Priv. Doz. Dr. Thomas Noll Second Supervisor and Committee Member: Prof. Dr. Henning Morawietz Committee Members: Prof. Dr. Ulrich Müller, Prof. Dr. Dr. Stefan Arnhold Date of Doctoral Defense: 08.09.2010 2 Table of contents Abbreviations 00 1. Introduction 09 1.1 Endothelial apoptosis 09 1.2 Reperfusion injury 10 1.3 Apoptosis in reperfusion injury 11 1.4 The intrinsic pathway 14 1.5 The extrinsic pathway 15 1.6 Inhibitors of apoptosis proteins 17 1.6.1 Structure and function of mammalian IAPs 18 1.6.2 Mechanism of caspase inhibition by IAPs 20 1.6.3 Regulation of IAPs 21 1.7 Postconditioning 23 1.7.1 Triggers and mediators of postconditioning 25 1.7.