Post-translational insertion of a small tail-anchored protein into the membrane of the endoplasmic reticulum [Elektronische Ressource] / presented by Milan Spasic

INAUGURAL - DISSERTATIONSubmitted to theCombined Faculties for the Natural Sciences and for MathematicsRupert-Karl-Universität Heidelbergfor the degree ofDoctor of Natural SciencesPresented byMaster of Science Milan Spasicfrom Belgrade, Serbia2005Date of oral examination:POST-TRANSLATIONAL INSERTION OF A SMALLTAIL-ANCHORED PROTEIN INTO THE MEMBRANEOF THE ENDOPLASMIC RETICULUMReferees:Professor Dr. Bernhard DobbersteinProfessor Dr. Irmgard SinningAcknowledgementsThis work has been accomplished in the lab of professor Bernhard Dobberstein in ZMBH,Heidelberg. I am grateful to Bernhard for his support, suggestions and patience...and most of all forsharing with me his overwhelming enthusiasm and joy of science. I take this opportunity also toacknowledge professor Irmgard Sinning for being my second referee.I would like to thank all the members of the lab for a friendship and support. Oliver Schlenkerfrom Irmi Sinning's group in BZH, Heidelberg, helped me a lot during experimental work. Thanks Olifor fruitful discussions, too (especially during meetings in Manchester pubs). My special thanks go toUte and Gerry, Mr. Anshuman, Christoph and Sabina. I was lucky to have you around, my friends. Itwas a great time...This work was not funded, but was heavily supported by members of the Heidelberg Serbian-Croatian-Bosnian community.Finally, I would like to dedicate this work and efforts put into it to two beautiful angels that arealways watching over me.