Polymorphism and expression of IL-10 in serum and ascites from patients with advanced ovarian cancer [Elektronische Ressource] / von Elena Ioana Braicu

Aus der Klinik für Gynäkologie/Campus Virchow Klinikum der Medizinischen Fakultät Charité – Universitätsmedizin Berlin DISSERTATION Polymorphism and expression of IL-10 in serum and ascites from patients with advanced ovarian cancer zur Erlangung des akademischen Grades Doctor medicinae (Dr. med.) vorgelegt der Medizinischen Fakultät Charité – Universitätsmedizin Berlin von Elena-Ioana Braicu aus Cluj-Napoca Gutachter/in: 1. Prof. Dr. med. J. Sehouli 2. Prof. Dr. med. C. Denkert 3. Prof. Dr. med. W. Friedmann Datum der Promotion: 04.02.2011 2 Contents 1 Introduction ............................................................................................................... 5 1.1 Ovarian cancer .. 5 1.1.1 Epidemiology ................................................................................................. 7 1.1.2 Etiology and risk factors ................ 8 1.1.3 Histological classification of epithelial tumors ............................................. 13 1.1.4 Grading ....... 16 1.1.5 The natural history of ovarian cancer .......................... 16 1.1.6 FIGO and TNM classifications .................................... 16 1.1.7 Prognostic factors ....................................................... 17 1.1.8 Screening .................................... 22 1.1.