PNA-ligand bioconjugates as potential building blocks for sequence-specific, metal-mediated DNA-RNA-cleavage [Elektronische Ressource] / presented by Tim Kersebohm

Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Dipl.-Chem. Tim Kersebohm born in Dortmund rdOral Examination: February 23 , 2005 PNA-Ligand Bioconjugates as Potential Building Blocks for Sequence-Specific, Metal-Mediated DNA-/RNA-Cleavage Referees: Prof. Dr. Nils Metzler-Nolte Prof. Dr. Andres Jäschke This work was carried out between December 2000 and November 2004 at the Institute of Pharmacy and Molecular Biotechnology, Department of Chemistry Ruperto-Carola University of Heidelberg, Germany Where is the Wisdom, We lost in Knowledge Where is the Knowledge, We lost in Information Where is the Information, We lost in Data T.S. Eliot (1888-1965) Acknowledgements I am very grateful to everybody who supported me during my work and life, no matter if professionally or personally. My gratitude especially concentrates on the following people: Prof. Dr. Nils Metzler-Nolte for luring me to Heidelberg and giving me the opportunity to face all challenges we had to overcome together while building up research and teaching in our department – the students will nevertheless appreciate that one day, I am sure… Prof. Dr.