Pharmacological studies of a novel inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway [Elektronische Ressource] / from Samy Abd El-Raouf Fahim Khalafalla Morad

From the Department of Veterinary Sciences Faculty of Veterinary Medicine LudwigMaximiliansUniversity of Munich Prof. Dr. Hermann Ammer Performed under the supervision of Prof. Dr. Thomas Simmet Institute of Pharmacology of Natural Products & Clinical Pharmacology Faculty of Medicine, Ulm University Pharmacological Studies of a Novel Inhibitor of the Mammalian Target of Rapamycin (mTOR) Signaling Pathway Inaugural Thesis for the Doctor Degree in Veterinary Medicine Faculty of Veterinary Medicine Ludwig Maximilians University of Munich From Samy Abd ELRaouf Fahim Khalafalla Morad from Qena, Egypt Munich 2010 Printed with the permission of the Faculty of Veterinary Medicine Ludwig Maximilians University of Munich Dekan: Univ.Prof. Dr. Braun Bericterstatter: Univ.Prof. Dr. Ammer Korreferent/en: Univ.Prof. Dr. Gabius Univ.Prof. Dr. Stangassinger Univ.Prof. Dr. Hirschberger Univ.Prof. Dr. Wanke Defence date: July 24, 2010 This work is dedicated to my parents, my wife, my son, my daughter, and the spirit of Abd El Mageed Foud C O N T E N T S Table of Contents ABBREVIATIONS..................................................................................................... IV 1. INTRODUCTION ...........