Pathomechanisms underlying the psoriasiform skin disease in CD18 hypomorphic PL-J mice [Elektronische Ressource] / vorgelegt von Honglin Wang

Universität Ulm Universitätsklinik für Dermatologie und Allergologie Ärztliche Direktorin: Prof. Dr. Karin Scharffetter-Kochanek Pathomechanisms underlying the psoriasiform skin disease in CD18 hypomorphic PL/J mice Dissertation zur Erlangung des Doktorgrades der Humanbiologie der Medizinischen Fakultät der Universität Ulm vorgelegt von Honglin Wang geb. in Nanjing, China Ulm, 2006 TABLE OF CONTENTS ABBREVIATIONS ....................................................................................................... 4 1. INTRODUCTION.............................................................................................. 7 1.1. Psoriasis........................................................................................................... 8 1.2.1. Clinical picture and histology of psoriasis .................................................. 9 1.2.2. Heredity of psoriasis .................................................................................. 9 1.2.3. The immunological synapse and psoriasis .............................................. 10 1.2.4. Animal models for psoriasis ......................................................................11 1.2.5. Immunological therapy in psoriasis.......................................................... 13 1.2. The CD18 hypomorphic PL/J mouse model of psoriasis................................ 15 1.2.1. Structure and function of CD18.............................