Patched-mediated regulation of smoothened trafficking and activity by Lipophorin-derived lipids [Elektronische Ressource] / von Helena Khaliullina-Skultety

Patched-mediated regulation of Smoothened trafficking and activity by Lipophorin-derived lipids D I S S E R T A T I O N zur Erlangung des akademischen Grades Doctor rerum naturalium (Dr. rer. nat.) vorgelegt der Fakultät Mathematik und Naturwissenschaften der Technischen Universität Dresden von Helena Khaliullina-Skultety geboren am 2. November 1982 in Kazan, Russland Gutachter: Prof. Dr. Elisabeth Knust Prof. Dr. Kai Simons Eingereicht am: 19. Mai 2010 Tag der Verteidigung: 27. Oktober 2010 …dedicated to my parents, who always answered my questions… Contrariwise, if it was so, it might be; and if it were so, it would be; but as it isn't, it ain't. That's logic. Alice laughed. 'There's no use trying,' she said. 'One can't believe impossible things.' ‘I daresay you haven't had much practice,' said the Queen. 'When I was your age, I always did it for half-an-hour a day. Why, sometimes I've believed as many as six impossible things before breakfast." — Lewis Carroll 1 TABLE OF CONTENTS 1. Declaration_______________________________________________________6 2. Summary_________________________________________________________7 3. Abbreviations_____________________________________________________9 4. Introduction 11 4.1 The morphogen Hedgehog in development, evolution and cancer 4.2 Routers of Hedgehog signaling 4.