Parametrising kinetic models of biological networks [Elektronische Ressource] / von Simon Borger

Parametrising kinetic models of biological networksDISSERTATIONzur Erlangung des akademischen GradesDr. rer. nat.im Fach Biophysik/Theoretische Biophysikeingereicht an derMathematisch-Naturwissenschaftlichen Fakultät IHumboldt-Universität zu BerlinvonDipl.-Phys. Simon Borgergeb. am 30.03.1975 in BerlinPräsident der Humboldt-Universität zu Berlin:Prof. Dr. Christoph MarkschiesDekan der Mathematisch-Naturwissenschaftlichen Fakultät I:Prof. Dr. Christian LimbergGutachter:1. Prof. Dr. Dr. h.c. Edda Klipp2. Prof. Dr. Hermann-Georg Holzhütter3. Prof. Dr. Thomas Höfer4. Prof. Dr. Matthias Reusseingereicht am: 28. Januar 2008Tag der mündlichen Prüfung: 10. Dezember 2008AbstractSystems biology seeks to model biological networks dynamically. Two require-ments need to be fulfilled for this to be possible. First, the interaction networksneed to be known. Second, the dynamics of the interactions have to be revealed.Dynamics of interactions are described by rate laws using kinetics. These kinet-ics describe the interaction mechanism. For each single interaction occurring ina biological network parameters have to specified. They have to be measured byexperiments. For enzyme catalysed reactions, for example, the parameters are mea-sured by enzyme assays tracking the consumption of substrate. For many enzymesparameters and kinetic mechanism are not known. And existing data for parame-ters generally are of poor quality.