Overexpression and analysis on posttranslational modification of the retinoic acid related orphan receptor {α4 [alpha-4] [Elektronische Ressource] / von Adriane Lechtken

Overexpression and analysis on posttranslational modification of the Retinoic Acid Related Orphan Receptor α4 Dissertation zur Erlangung des Doktorgrades der Naturwissenschaften vorgelegt beim Fachbereich Biochemie, Chemie und Pharmazie der Johann Wolfgang Goethe-Universität in Frankfurt am Main von Adriane Lechtken aus Erlangen Frankfurt am Main (2007) (D30) Vom Fachbereich Biochemie, Chemie und Pharmazie der Johann Wolfgang Goethe-Universität als Dissertation angenommen. Dekan: Prof. Dr. Harald Schwalbe Gutachter: Prof. Dr. Dieter Steinhilber Prof. Dr. Oliver Werz Datum der Disputation: 30.08.2007 “There is a theory which states that if ever anybody discovers exactly what the Universe is for and why it is here, it will instantly disappear and be replaced by something even more bizarre and inexplicable. There is another theory which states that this has already happened.” (Douglas Adams) CONTENTS 1 INTRODUCTION ........................................................................1 1.1 Nuclear Receptors......................................................................................................1 1.1.1 Structure of Nuclear Receptors .......................................................................... 3 1.1.2 Hormone Response Elements (HREs) ...............................................................