Optoacoustic characterization of optical properties of human skin in vivo in the ultraviolet wavelength range [Elektronische Ressource] : skin phototypes, UV-adaptations and effects of sunscreen / von Merve Meinhardt

OptoacousticCharacterizationofOpticalPropertiesofHumanSkininVivointheUltravioletWavelengthRangeskinphototypes,uv adaptationsandeffectsofsunscreenVonderNaturwissenschaftlichenFakultätderGottfriedWilhelmLeibnizUniversitätHannoverzurErlangungdesGradesDoktorinderNaturwissenschaftenDr. rer. nat.genehmigteDissertationvonDipl. Phys. MerveMeinhardtgeborenam10.11.1976inHannover(2006)Referentin: Prof. Dr. AngelikaAnders vonAhlftenInstitutfürBiophysik,GottfriedWilhelmLeibnizUniversitätHannoverKorreferent: PDDr. HolgerLubatschowskiLaserZentrumHannovere.V.TagderPromotion: 19.7.2006AbstractTheambitionofthisdissertationprojectwasthedevelopmentandapplicationofanexper-imental setup to determine the optical properties of human skin in vivo in the ultravioletwavelengthrange.Optoacousticswaschosenastheappropriatetechniqueallowingnon invasive,depthsre solved determination of optical properties. It is a hybrid technique using short pulsedradiation to induce a pressure profile in the skin which carries the information about thelight distribution and which is released in an ultrasonic transient unhamperedly travelingbacktothepressuresensorabovetheskin.Accordingly, the first part of the thesis at hand deals with the development of the neces saryexperimentalandanalyticaltoolsfortheinvivoinvestigations.During this dissertation project, a previous first design of the optoacoustic detector wasoptimizedaccordingtothedemandsofsensitivehumanskin.