Opioidergic modulation of luteinizing and growth hormone release from porcine adenohypophyses in vitro [Elektronische Ressource] / von Enowmpey Enowtambong

Opioidergic modulation of luteinizing and growth hormone release from porcine adenohypophyses in vitro Von dem Fachbereich Biologie der Universität Hannover zur Erlangung des Grades eines Doktors der Naturwissenschaften Dr. rer. nat. Genehmigte Dissertation von Enowmpey Enowtambong (B.Sc., M.Sc.) geboren am 26.03.68 in Fumbe-Mamfe/ KAMERUN 2002 Referentin: Frau Prof. Dr. Dr. N. Parvizi Korreferentin: Frau Prof. Dr. C. Aurich Korreferent: Prof. Dr. S. Steinlechner Tag der Promotion : 14 .06. 2002 This research work was carried out at the Federal Research Centre for Agriculture, FAL, Institute for Animal Science and Animal Behaviour, Mariensee, 31535 Neustadt, Republic of Germany. ABSTRACT Endogenous opioids are known to modify LH and GH secretion through the hypothalamo- pituitary axis. This study aimed at verifying the direct action of opioids on LH and GH secretion at the pituitary level using pituitaries (adenohypophyses) of pigs in a perifusion in vitro system. Furthermore to determine whether opioidergic modulated release of LH and GH is altered by LHRH or GHRH stimulation at the pituitary in pigs and if these effects are sex-, and age-dependent.